Starting semaglutide for weight loss? You’ve likely heard about nausea and digestive changes. But some people notice other unexpected symptoms, like feeling colder than usual, mild swelling, fatigue, or changes in taste.
While not everyone experiences these effects, understanding what can happen — and how to respond — helps you feel more prepared. At Emerson Medical on Staten Island, we believe clear, medically guided information supports a smoother weight loss journey.
Decoding the Discomfort: Common GI Side Effects Explained
Digestive changes are among the most frequently reported side effects of semaglutide. Nausea, mild stomach upset, and changes in bowel habits may occur, especially when first starting treatment or adjusting the dose.
Why GI Issues May Happen
Semaglutide works by mimicking a hormone called GLP-1, which plays a role in appetite and digestion. It slows how quickly food leaves the stomach. This effect can increase fullness but may also contribute to:
Nausea
Bloating or abdominal discomfort
Constipation or diarrhea
Feeling full sooner than expected
These symptoms are often more noticeable early in treatment and may lessen as the body adjusts.
What May Help
Some people find it helpful to:
Eat smaller meals more frequently
Choose lower-fat, easy-to-digest foods
Stay consistently hydrated
Sip fluids slowly throughout the day
Try mild options like ginger or peppermint tea
If symptoms persist, worsen, or interfere with eating, your provider may adjust your treatment plan or offer supportive options.
Understanding Swelling or Fluid Retention
Some individuals report noticing mild swelling in areas such as the fingers, ankles, or face while on semaglutide. Swelling can have many possible causes, and it is not always directly related to medication.
Potential contributing factors may include:
Changes in diet or sodium intake
Reduced physical activity
Hormonal shifts associated with weight changes
Underlying medical conditions
Because swelling can stem from a variety of causes, it is important to discuss any new or persistent symptoms with your provider.
When to Contact Your Provider
Seek medical attention promptly if swelling is:
Sudden or severe
Associated with pain, redness, or warmth
Accompanied by shortness of breath
Paired with rapid, unexplained weight gain
When in doubt, it is always appropriate to check with your healthcare provider for guidance.
Feeling Colder or More Tired Than Usual
Some people report feeling cooler or more fatigued after beginning semaglutide or during weight loss in general. Changes in calorie intake, hydration, sleep, or daily routines may contribute to these sensations.
To support overall energy levels:
Maintain balanced nutrition
Stay hydrated
Incorporate gentle, regular movement
Prioritize consistent sleep habits
If fatigue is significant, persistent, or interfering with daily life, your provider may evaluate for other contributing factors.
Navigating Nausea and Taste Changes
Nausea may be accompanied by changes in taste. Some people describe altered flavor perception or reduced appetite for certain foods.
Strategies that may help include:
Choosing bland, simple foods such as rice, toast, bananas, or oatmeal
Avoiding foods that seem to trigger symptoms
Trying cooler or room-temperature meals
Using mild flavor additions like lemon or ginger
Drinking fluids gradually throughout the day
If appetite becomes very limited or you are struggling to maintain adequate nutrition, your provider may recommend additional support.
Supporting Nutrition During Treatment
During weight loss, preserving muscle mass and overall nutrition remains important. Many patients benefit from prioritizing protein intake and balanced meals. Because nutritional needs vary, a registered dietitian or medical provider can help determine an appropriate plan based on your individual health profile.
Addressing Sleep Disturbances and Headaches
Some individuals report sleep changes or headaches during the early stages of semaglutide treatment. These symptoms may relate to hydration status, changes in food intake, stress, or other factors.
To support sleep:
Maintain a consistent bedtime routine
Limit late-day caffeine
Reduce screen exposure before bed
For headaches:
Ensure adequate fluid intake
Take breaks from screens
Use relaxation techniques as appropriate
If headaches are severe, frequent, or worsening, contact your provider for evaluation.
The Role of Hydration
As appetite decreases, some individuals unintentionally reduce their fluid intake. Staying hydrated may support digestion, energy levels, and overall comfort during treatment.
Setting reminders to drink fluids throughout the day can be helpful. Your provider can guide you on appropriate hydration goals based on your individual needs.
Proactive Strategies for Managing Side Effects
Each person’s response to semaglutide is unique. A thoughtful, medically supervised approach can improve comfort and safety.
Helpful practices may include:
Gradual Dose Adjustments
Dose changes are typically introduced slowly under medical supervision. Always follow your provider’s instructions and avoid altering your dosage without guidance.
Tracking Symptoms
Keeping a simple log of symptoms, meals, and timing may help identify patterns and guide discussions with your provider.
Balanced Nutrition
Regular meals that include protein, fiber, and healthy fats may support stable energy levels.
Open Communication
Promptly reporting new or worsening symptoms allows your provider to tailor your treatment plan appropriately.
Side effects are not uncommon with GLP-1 medications, and most can be addressed with proper monitoring and support.
Get Expert Support for Your Semaglutide Journey on Staten Island
Navigating semaglutide treatment can feel overwhelming, especially if unexpected symptoms arise. Dr. Chalik and the team at Emerson Medical provide medically supervised GLP-1 weight-loss care on Staten Island, with close monitoring and individualized guidance.
If you are experiencing nausea, fatigue, swelling, changes in taste, or other concerns, a professional evaluation can help ensure your treatment remains safe and aligned with your goals.
Call (718) 448-3800 to schedule your consultation with Dr. Chalik today and receive personalized support throughout your semaglutide journey.
Schedule a Free Consultation
SIGN UP ONLINE OR CALL 718-448-3800
